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Besides, the roles of Gaba in the attenuation of gut inflammation and improvement of gut epithelial barrier were suggested via inhibiting IL-8 production and stimulating the expression of tight junction proteins as well as the expression of TGF-β cytokine in Caco-2 cells [103]

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Nitric oxide was named “Molecule of the Year” by Science magazine in 1992 due to its widespread importance in human biology