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In addition, Pycnogenol ® downregulated other pigmentation-related mediators in UV-light treated human melanocytes ( ® ’s ability to counteract skin hyperpigmentation was clinically validated in another study ( ® was shown to significantly lower UV-induced expression of the pigment synthesizing enzymes TRP1 by 75%, tyrosinase by 51%, MITF by 67% and MART-1 by 67%

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In pregnant women, for every unit increase in MCV, there was a 19% increase in odds of abnormal methylmalonic acid, OR 1.19 (95% C.I