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DAO is an enzyme found in the gut that metabolizes histamine in the GI tract, which can be a significant source of histamine, especially in the presence of SIBO, candida overgrowth and certain pathogenic infections like For more information you can read Thakkar, 2011 ) High levels of histamine in the body can impair sleep

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Patients with PCOS display characteristic gut microbiota dysbiosis, though specific compositional alterations remain inconsistently reported across studies ( The gut microbiota and its metabolites play an important role in iron metabolism