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Also, CAR-T cells directed to PDPN by a construct composed of NZ-1-based single-chain variable fragments and CD28, 4-1BB and CD3 ζ intracellular domains have shown good efficiency against glioma cells both in vitro and in vivo glioma xenografts (277)

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Inhibition of endothelial notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart