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A revised reference list of genotoxic and non-genotoxic chemicals recommended for assessing the performance of new or improved in vitro genotoxicity test methods has been developed to fit the following different sets of characteristics (Kirkland et al., 2016): Group 1: Chemicals that should be detected as positive in in vitro mammalian cell genotoxicity tests

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2c) and accumulation of damaged mitochondria and lipid droplets in the GLA-mutant kidney organoids (Fig