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FDA approval in 2021 based on its ability to reduce cerebral amyloid plaques, although its clinical benefit remains controversial due to inconsistent Phase III outcomes (Sevigny et al., 2016

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Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib: The CheckMate 040 Randomized Clinical Trial