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Less common but more serious risks include pancreatitis, gallbladder disease, hypoglycemia (when used with insulin/sulfonylureas), kidney injury (with severe dehydration), and retinopathy worsening in patients with pre-existing diabetic retinopathy

Carbohydrate metabolism

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In addition, this channel has also been classically described to be activated by organic compounds such as menthol, eucalyptus, and ilicin (Jimenez et al., 2020