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cyclisation broadens agonist activity across MC1R, MC3R, MC4R and MC5R and increases resistance to proteolytic cleavage, giving the non-selective profile that makes it the usual positive-control agonist in receptor assays

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Furthermore, the translocation of the VDR/1,25(OH)2VD complex is induced by the upregulation of VDR expression in target tissues, making it available for metabolic action, such as GLUT4 upregulation