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Elevated levels of IL-6, IL-10 and TNF-α and increased expression of immune checkpoint markers such as PD-1 and T-cell immunoglobulin mucin-3 (Tim-3) on the surface of peripheral T cells, reduce T-cell function and memory T-cell activity (143, 144)

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85 In hepatic I/R induced by Pringle’s maneuver, BPC 157 preserved sinusoidal structure, limited necrosis, and attenuated inflammatory infiltration