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Interestingly, clinical studies using NAC have shown a modest ability to promote abstinence from cocaine, cannabis, and nicotine (reviewed in McClure et al., 2014), providing additional, albeit indirect, support for the idea that increasing mGlu 2 activity could reduce drug seeking in humans

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[DOI] [PubMed] [Google Scholar] 96.Yang C, Zhao T, Lin M, Zhao Z, Hu L, Jia Y, et al