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Edema (limited use due to weak diuretic effect) Side Effects: - Metabolic acidosis (due to bicarbonate loss) - Hypokalemia - Paresthesia (tingling) - Renal stones (alkaline urine increases stone risk) - Drowsiness, confusion - Sulfa allergy reactions (as CAIs are sulfonamide derivatives) Contraindications: - Severe hepatic or renal dysfunction - Addison’s disease - Pre-existing electrolyte imbalance - Sulfonamide hypersensitivity Precautions: - Monitor serum electrolytes and acid-base balance - Use with caution in patients with pulmonary obstruction (CO₂ retention risk) Pregnancy Category: Use with caution — topical forms (e.g., dorzolamide) may be safer than systemic forms

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