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Funding This work was funded by RETOS projects Programme of Spanish Ministry of Science, Innovation and Universities, Spanish State Research Agency (AEI/10.13039/501100011033), co-funded by the European Regional Development Fund (Grant SAF2015-67538-R and PID2019-104012RB-I00), EU-H2020 Programme (ERC-2014-STG-638891), Excellence Network Grant from MICIU/AEI (SAF2016-81975-REDT), a Ramon y Cajal Award from MICIU/AEI (RYC-2013-13546), a Lab Grant from the Spanish Association Against Cancer Research Scientific Foundation (AECC), Beca de Investigación en Oncología Olivia Roddom, and FERO Grant for Research in Oncology (to AE)