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In particular, processes related to the endoplasmic reticulum quality control, such as the UPR, have been shown to be impaired in BD, with evidence of lower URP activation in response to tunicamycin- or thapsigargin-induced ER stress [220, 221], as well as increased binding immunoglobulin protein (Bip) and decreased X-box binding protein 1 (XBP1) splicing [222] in cells from individuals with BD

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As for the second clinical trial, it is a phase 1/2 multi-arm and multi-site interventional trial beginning in 2020, examining safety profiles, efficacy, and tolerability of stem cell application within treating several chronic and acute disorders such as neurodegenerative disorders, including AD [61]