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After T cell stimulation, TXNIP is rapidly downregulated, relieving the inhibition on the TRX1 system

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The Nrf2/HO-1 pathway suppresses ferroptosis by upregulating antioxidant enzymes ( 2.2 Ferroptosis in OSCC: tumor biology, immune modulation, and therapy resistance Research on ferroptosis in OSCC began only recently, yet it has rapidly become a focal point at the intersection of tumor metabolism and cell-death biology