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[DOI] [PubMed] [Google Scholar] 117.Khanani A.M., Kotecha A., Chang A., Chen S.-J., Chen Y., Guymer R., Heier J.S., Holz F.G., Iida T., Ives J.A., et al

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Size:240 Servings

The foundational discovery behind it wasn’t even a drug study: researchers genetically silenced the NNMT gene in obese mice and observed dramatic reductions in fat mass, which established NNMT as a worthwhile target but said nothing about how a small-molecule inhibitor would behave