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In the presence of cytokines and growth factors, STAT3 is phosphorylated by receptor-associated tyrosine kinases, and this phosphorylation allows STAT3 to form homo- or heterodimers that translocate to the cell nucleus, where they act as activators of transcription [210]

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Mitochondria (the “power plants” inside cells) don’t work well in neuropathy, which lowers energy (ATP) and produces harmful molecules called free radicals