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To avoid DMSO toxicity 11,12 , we designed water-soluble versions of CSD and its subregions (designated sCSD, sA, sB, sC, Table 1)

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The 28-day figure is from USP General Chapter 797 , which sets a beyond-use date for multi-dose vials as a category, and it is explicitly conditional: a multi-dose vial may be used for 28 days after first puncture unless the manufacturer states otherwise