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For instance, in neuronal cells exposed to PD‐related stressors (like rotenone or α‐synuclein aggregates), polyphenols prevent cell death: resveratrol reduces apoptosis of PC12 dopaminergic cells by upregulating HO −1 and other antioxidant defenses [39, 62]

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N-acetylcysteine amide has been reported to inhibit H2O2-induced cataract formation ex vivo at concentrations of 0.1 to 10 mM (144), as well as selenite and l-buthionine-(S, R)-sulfoximine-induced cataracts in vivo at an intraperitoneal injection dose of 250 mg/kg/day (145,146)