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HDL also prevents thrombus formation through cell signaling and nitric oxide (NO) production in endothelial cells (828), and suppression of tissue factor and platelet-activating factor expression in endothelial cells (833,834)

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However, the increasing number of resistant strains significantly reduces the efficacy of treatment, making clinical management more difficult and raising worries about their effects on public health ( Natural products, particularly those derived from aromatic and medicinal plants, have drawn more attention as potential sources of new antimicrobial chemicals