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Conversely, these organoids also exhibited upregulation of a cluster of genes which included GCLC, SAT1, FTL, HMOX1, SLC39A14 TP53 and SAT2 (Fig

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This anabolic phase is characterized by robust glycolytic activity, one-carbon metabolism, fatty acid synthesis and mitochondrial respiration and biogenesis, and is fueled by the large consumption of nutrients like glucose, glutamine, leucine, arginine and imported fatty acids 173