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Two mammalian bombesin-like peptides (BLPs) having a widespread distribution in the central nervous system (CNS) and gastrointestinal (GI) tract [47] were discovered so far: gastrin-releasing peptide (GRP), with a higher affinity towards G-protein-coupled GRP receptor, and neuromedin B (NMB) binding to the NMB receptor

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Second, there is preclinical efficacy evidence , which asks whether that mechanism changes tissue or organism-level outcomes in animal models