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To understand whether this effect of IGF-1 on IL-17 production is dependent on IR or IGF-1R signaling, we activated splenic CD4 + T cells from IR conditional knockout (cKO) mice ( CD4Cre + IR fl/fl ) or IGF-1R cKO mice ( CD4Cre + IGF1R fl/fl ) and littermate controls in full serum conditions and measured IL-17 production by ELISA

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J., van Woerkom, G