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Their immunomodulatory functions include regulating cytokine production, influencing immune cell recruitment to the wound site, suppressing excessive inflammation by downregulating TNF-α, IL-6, and other pro-inflammatory mediator, and enhancing phagocytosis by modulating macrophage activity to facilitate the clearance of necrotic tissue and pathogens (Duan et al., 2022[29]), In addition, AMPs are highly effective against multidrug-resistant bacteria, as they target bacterial membranes, making it difficult for pathogens to develop resistance (Pervin and Hassan, 2021[105])

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J Proteome Res 11(7):3605–3623