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Considering that both carnitine and synbiotics are perceived to induce beneficial effects on glycemic indices ( Various clinical trials have demonstrated the promising effects of L-carnitine on insulin sensitivity and/or glucose tolerance ( Several mechanisms are suggested for the beneficial impacts of L-carnitine on glucose homeostasis, including improving insulin sensitivity, enhancing glucose utilization, modulating the gluconeogenic and glycolytic enzymes expression, altering the insulin signaling cascade gene expression, and stimulating the insulin-like growth factor 1 (IGF-1) axis and IGF-1 signaling cascade ( It has been clarified in several clinical trials that pro/pre/synbiotics might improve glucose homeostasis features ( The putative mechanisms for the ameliorating effects of synbiotics on glycemic status principally mediated through amplifying SCFA production could be considered as four principal issues, namely, ameliorating glucose homeostasis, attenuating insulin resistance, amending gut integrity, and hindering proinflammatory signaling pathways ( Collectively, mounting data support the ameliorating impacts of either synbiotics or L-carnitine on obesity, lipid profile, or glycemic markers although distinctions in metabolic modifying agents, such as the participants’ ethnic group, genotype, health condition, dietary intake, physical activity, and baseline values of biological markers, along with formulation, dose, and supplementation length, might have resulted in diverse reports
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