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Its modulation favors the improvement of interstitial fibrogenesis (Wan et al., 2022)

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At the molecular level, kaempferol inhibited the overexpression of TNF-α receptors (TNFR1 and TNFR2), phosphoinositide 3-kinases (PI3Ks), protein kinase B (AKT), and Smad2/3 in cardiac tissue, as well as p-nuclear factor kappa B (NF-κB) and transforming growth factor beta 1 (TGF-β1) in vascular tissue