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372,373 Moreover, the ε-face of Cu I -coordinated His ligand interacts with residues in the second coordination shell including nearly invariant Tyr and Glu residues that are energetically linked to Cu I -mediated allosteric inhibition of DNA binding, suggesting a path for allosteric connectivity

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“The products themselves are unregulated ‘research compounds’ of uncertain purity, dose, and composition,” he adds