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High levels of expression of the isoform of NADPH oxidase (NOX)—NOX5, generators of RONS in sperm—have been reported in both teratozoospermia [50] and asthenozoospermic human ejaculates [37]

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Despite the differences between pRCC type 1 and 2, some metabolic alterations are shared, including reduced expression of enzymes involved in gluconeogenesis, fatty acid metabolism, the TCA cycle and OXPHOS 104