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doi: 10.1111/j.1600-0781.2011.00614.x

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On the other hand, activation of AMPK by metformin has been shown to induce the phosphorylation of serine 195 of PD-L1, leading to abnormal glycosylation and finally the degradation of PD-L1 through ER-associated protein degradation (ERAD) 96

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