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As a supplement, NMN is much more orally bioavailable than NAD+.18 That, coupled with the fact that it’s just one step removed from becoming NAD+ in the salvage pathway — as opposed to NR, which must first be converted to NMN — means it’s theoretically the best choice for an NAD+ booster

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Even determining which form of the peptides should be used was unclear to regulators, since substances like TB-500 aren’t recognized as official pharmaceutical ingredients in the U.S