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Common B12 deficiency symptoms include fatigue, anxiety, depression, poor memory, confusion, brain fog, tingling or numbness in the extremities, zings or zapping feelings in the extremities, anemia, shortness of breath, muscle weakness, irritability, tender calves, pale complexion and more.

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My clinical observation has seen it numerous times where children prior to Methyl-B12 therapy were at the bottom of their classes but within one to two years climbed to the top of their classes or were moved to new more challenging classrooms