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188,189 Moreover, upregulation of miR-19a, miR-371b-5p, and METTL3 in PAH inhibit cell apoptosis by suppressing phosphatase and tension homolog, a key inhibitor of the PI3K/Akt pathway, in PASMCs and PAECs

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Alterations in catalase activity observed in individuals with IBD suggest a potential imbalance in antioxidant defenses, warranting further investigation into the therapeutic strategies targeting catalase to mitigate oxidative damage and inflammation in the gastrointestinal mucosa [100,101]