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Finally, some commonly used drugs (e.g., glucocorticoids and GLP-1RAs) can also affect intra-portal insulin levels that modulate the GH/IGF-I axis either by increasing or decreasing hepatic GH sensitivity, as reflected by the discordant GH and IGF-I levels

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1 H NMR (DMSO, 600 MHz): δ 2.42 (s, 9H) 4.48 (d, 6H, J = 5.5 Hz) 5.13 (t, 3H, J = 5.5 Hz) 5.66 (s, 6H) 7.76 (s, 3H)