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Regarding the former, the “free radical theory of aging” postulates that the loss of balance between prooxidants and antioxidants leads to accumulation of oxidative damage in macromolecules with age, which plays an important role in age-related disturbances in cellular processes [35]

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Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease