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Recent research suggests that metformin may also alter the gut microbiota, through the protection of the intestinal barrier, promotion of SCFAs producing bacteria growth, regulation of bile acids plasmatic levels and their excretion, and direct regulation of growth of bacteria with a positive effect on glucose homeostasis (eg., Akkermansia muciniphila ) (Zhang and Hu, 2020)

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In a landmark study, Khavinson demonstrated that epitalon increased telomerase activity in human fibroblast cells, extending their proliferative lifespan from 34 passages to beyond 44 passages

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