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Acknowledgements This work was financially supported by the National Natural Science Foundation of China (NSFC 52322309 and 52173139), the “Young Talent Support Plan” of Xi’an Jiaotong University, and Fundamental Research Funds for the Central Universities (xzy022021040, xzy022021052, xzy012023098, and xzy012023105)

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Some researchers have speculated that patients in certain clinical trials, particularly the CASTA stroke trial, may have received inadequate doses, potentially explaining the mixed results in the overall population analysis