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It can also be a result of changes in capital conditions since early-phase studies are often riskier as an entry point compared to later-phase studies that have already cleared a sizeable portion of safety and regulatory validations, leading sponsors to be more selective about the studies they are initiating

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[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Sattar N., Lee M.M.Y., Kristensen S.L., Branch K.R.H., Del Prato S., Khurmi N.S., Lam C.S.P., Lopes R.D., McMurray J.J.V., Pratley R.E., et al