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Current Usage Patterns • How Tylenol Is Metabolized: The Three Pathways • How Pregnancy Changes Acetaminophen Metabolism • What Slows and Speeds Up Your Detox Enzymes • The Toxicity of NAPQI: Why This Metabolite Is Dangerous • Who May Be at Higher Risk

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Financial support and sponsorship This work was supported by NIH grants R01HL169291 (to Lee RT), R35GM134923 and R01AG072087 (to Thompson TB), R01AG057428 and an award from the Glenn Foundation (to Wagers AJ), and R01AG072086 (to Rubin LL and Wagers AJ)