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As an illustration, evidence has been put forward to the effect that the delivery of liposomal formulations of doxorubicin is capable of circumventing P-gp-driven efflux through the encapsulation of the drug in a lipid bilayer that prevents direct drug interaction with the pump and increases intracellular drug accumulation [333]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.de Souza I., Ramalho M.C.C., Guedes C.B., Osawa I.Y.A., Monteiro L.K.S., Gomes L.R., Rocha C.R.R