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Here we report the cryo-electron microscopy (cryo-EM) structures of CCK1R–G s signaling complexes liganded either by sulfated cholecystokinin octapeptide (CCK-8) or a CCK1R-selective small-molecule SR146131, and CCK2R–G q complexes stabilized by either sulfated CCK-8 or a CCK2R-selective ligand gastrin-17