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In acute gouty arthritis, traditional Chinese medicine formulations have been used to suppress caspase-1 activation and IL-1β production, thereby inhibiting NLRP3 inflammasome activation and pyroptosis in THP-1 cells, ultimately improving disease outcomes (Wang N

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For example, studies of healthy females found that the low level of serum folate in 677TT genotype is associated with an increase in homocysteine concentration and DNA hypomethylation 91,92 , which reveals the association between MTHFR C677T polymorphisms and nutrient status