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Overall, the metabolic disturbances associated with diabetes not only worsen mitochondrial dysfunction but also intensify oxidative damage to cardiomyocytes through ferroptosis

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Following GSL hydrolysis by the myrosinase enzyme, the ITC derivatives, absorbed in the intestine, are metabolized through the mercapturic acid pathway, primarily through the conjugation with GSH by GST, with the formation of a dithiocarbamate GSH-conjugate