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The first and rate-controlling reaction of heme biosynthesis is the mitochondrial formation, catalyzed by ALA synthase, of delta-aminolevulinic acid (ALA) from succinyl CoA, generated within the tricarboxylic acid cycle, and glycine [136]

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[74] To address dysbiosis, we want to start shifting the microbiome in a positive direction by increasing levels of beneficial bacteria, and decreasing levels of pathogenic bacteria