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According to Kannt & Pfenninger in Frontiers in Physiology , NAD⁺ is a critical coenzyme in mitochondrial energy metabolism, and strategies that preserve NAD⁺ have wide-ranging effects on health and performance (Kannt & Pfenninger, Frontiers in Physiology )

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Lymphatic absorption is a significant contributor to the subcutaneous bioavailability of insulin in a sheep model