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DISCUSSION In the present study, we found that in human testes FOXO4 was specifically expressed in Leydig cells, that FOXO4 showed nuclear translocation in Leydig cells within old testes, and that the nuclear translocation of FOX04 was related to decreased testosterone synthesis

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reported that salvianolic acid A ( 17 ) played a significant role in improving kidney injury in rats, and the mechanism may be achieved by regulating the MAPK and TGF-β1/Smad protein (Smad) signaling pathways [122]