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A2ARi treatment caused enhanced expression of gls , gls2 , gclm , gclc , and slc7a11 (which encode the key enzymes and transporter for glutamine-derived GSH biosynthesis) as well as slc25a39 (which encodes the only mitochondrial membrane transporter for mitochondrial GSH import), driving the de novo GSH biosynthesis and the mitochondrial GSH-import machinery, respectively (Supplemental Figure 6C)

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