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Induction of Oxidative Stress by Glutathione Depletion Causes Severe Hypertension in Normal Rats | Hypertension

14 On the one hand, GSH reductase converts GSSG to GSH using NADPH as an important cofactor, then GSH acts as a cosubstrate for GSH peroxidase (GPX) that reduces hydrogen peroxide (H 2 O 2 ) and other peroxides to H 2 O or alcohol to deactivate ROS

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Inactivation of Rab4A in T cells abrogated proteinuria in female B6.TC/Rab4A Q72L -KO mice (0.56 ± 0.11 μg/μl) in comparison to B6.TC/Rab4A Q72L female controls (1.11 ± 0.19 μg/μl