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Agonist and knockout studies have revealed that FXR also plays a role in keeping postabsorptive pathways in check, including inhibiting SREBP-1c-driven fatty acid and triglyceride synthesis and promoting triglyceride lipolysis by inhibiting apolipoprotein C3 (APOCIII) and angiopoietin-like 3 (ANGPTL3) (Claudel et al