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Despite its strength, dexamethasone has minimal mineralocorticoid (salt-retaining) activity , so it causes very little fluid or sodium retention compared to some other steroids

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The largest placebo-controlled study (Hendren et al., 2016, USA) reported that over half of treated children were rated as improved by clinicians (versus ~30% on placebo), and biochemical improvements in methylation indices were noted, yet caregiver-rated social behaviors did not differ significantly from placebo [25]