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IFIH1 encodes melanoma differentiation-associated protein 5 (MDA5), a ubiquitously expressed cytoplasmic RNA helicase and sensor that is crucial to survival after systemic viral infection by inducing an MAVS-mediated type I IFN immune response (98)

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420 Two population‐based studies found higher rates of cognitive impairment among SGM older adults than among non‐SGM older adults, 421 , 422 yet a third study reported that the risks for dementia and mild cognitive impairment were similar for people in same‐sex relationships and people in another‐sex relationships