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NNMT inhibition → preserved nicotinamide substrate pool Reduced nicotinamide methylation → conserved S-adenosyl methionine Elevated intracellular NAD+ → increased sirtuin pathway activity Adipocyte metabolic shift → altered lipid handling in cell models Core Areas of Scientific Investigation NNMT Enzyme Inhibition: NNMT activity is elevated in adipose tissue in obesity models

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Pharmacotherapy of Obsessive-Compulsive Disorder and Obsessive-Compulsive Spectrum Disorders